|
KMID : 0361120050190020137
|
|
Korean Journal of Transplantation
2005 Volume.19 No. 2 p.137 ~ p.141
|
|
|
Clinical Significance of C4d-Positivity in Renal Transplant Recipients with Acute Rejection
|
|
정병하/Chung BH
정희선/전상훈/박용재/최선욱/윤정민/최범순/최영진/양철우/김용수/강창석/Jung HS/Jeon SH/Park YJ/Choi SO/Yoon JM/Choi BS/Choi YJ/Yang CW/Kim YS/Kang CS
|
|
|
Abstract
|
|
|
Purpose: C4d detection in peritubular capillaries in acute allograft rejection has been regarded as a poor prognostic factor for graft kidney survival. We investigated the clinical importance of C4d positivity in renal transplant recipients with acute rejection.
Methods: Forty eight renal allograft biopsies were selected, which were available for immunofluorescence study. The samples were divided into two groups, one which was diagnosed as acute rejection clinically (n=30), the other which underwent protocol biopsy 2 weeks after transplantation (n=18). Among the acute rejection group, C4d staining was positive in 50% of acute rejection cases (C4d (+), n=15) and negative in the others. (C4d (-), n=15). We compared the C4d (+) group and the C4d (-) group in terms of clinical parameters and graft survival duration.
Results: Renal function was reduced in the C4d (+) group compared to the C4d (-) group. In the C4d (+) group, 8 of 15 cases resulted in graft loss, but only one graft loss developed in the C4d (-) group. Graft survival duration after kidney biopsy was reduced in the C4d (+) group compared to the C4d (-) group.
Conclusion: Renal transplant recipient with C4d-positive acute rejection shows inferior graft survival duration. So tight management in addition to steroid pulse therapy should be considered for these patients.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|